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    Frontiers in Pharmacology of Neurotransmitters

    Numerous phenomenal advances have been made towards understanding the role of neurotransmitters in the pathophysiology of neurological disorders, and these have resulted in a large number of novel molecules with the potential to revolutionize the treatment and prevention of such disorders. This book provides a comprehensive and detailed explanation of brain neurotransmitters and their receptors and associated channels.It includes a basic introduction, and also discusses the functions and recent advances and their pharmacology, highlighting the role of various computer aided drug design (CADD) strategies for the development of therapeutic ligands to modulate these receptors/ion channels.Written in an easy-to-read style, it is intended for neuroscience and pharmaceutical students and researchers working in the area of brain neurotransmitters.

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    Fashion and Environmental Sustainability : Entrepreneurship, Innovation and Technology

    The wide range of topics that the book covers are organised into sections reflecting a cradle to grave view of how entrepreneurial, innovative, and tech-savvy approaches can advance environmental sustainability in the fashion sector.These sections include: sustainable materials; innovation in design, range planning and product development; sustainable innovations in fashion supply chains; sustainable innovations in fashion retail and marketing; sustainable alternatives for end-of-life and circular economy initiatives; and more sustainable alternative fashion business models.

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    The sustainable development of our planet depends on the use of energy. The growing population of the world inevitably causes an increase in the demand for energy, which, on the one hand, threatens the potential for shortages of energy supply, and, on the other hand, causes the deterioration of the environment.Therefore, our task is to reduce this demand through different innovative solutions (i.e., both technological and social). Social marketing and economic policies can also play a role in affecting the behavior of households and companies, by causing behavioral change oriented to energy stewardship, and an overall switch to renewable energy resources. This book provides a platform for the exchange of a wide range of ideas, which, ultimately, would facilitate the driving of societies to long-term energy efficiency.

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  • Dynamic Efficiency and Productivity Measurement
    Dynamic Efficiency and Productivity Measurement

    A systematic treatment of dynamic decision making and performance measurementModern business environments are dynamic.Yet, the models used to make decisions and quantify success within them are stuck in the past.In a world where demands, resources, and technology are interconnected and evolving, measures of efficiency need to reflect that environment. In Dynamic Efficiency and Productivity Measurement, Elvira Silva, Spiro E.Stefanou, and Alfons Oude Lansink look at the business process from a dynamic perspective.Their systematic study covers dynamic production environments where current production decisions impact future production possibilities.By considering practical factors like adjustments over time, this book offers an important lens for contemporary microeconomic analysis.Silva, Stefanou, and Lansink develop the analytical foundations of dynamic production technology in both primal and dual representations, with an emphasis on directional distance functions.They cover concepts measuring the production structure (economies of scale, economies of scope, capacity utilization) and performance (allocative, scale and technical inefficiency, productivity) in a methodological and comprehensive way. Through a unified approach, Dynamic Efficiency and Productivity Measurement offers a guide to how firms maximize potential in changing environments and an invaluable contribution to applied microeconomics.

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  • Where exactly are neurotransmitters formed?

    Neurotransmitters are formed in the axon terminals of neurons. These are the small, bulb-like structures at the end of the neuron's axon. Within the axon terminals, neurotransmitters are synthesized from various precursors and then stored in vesicles until they are released into the synapse to transmit signals to other neurons. The process of neurotransmitter formation and release is crucial for communication between neurons and for the proper functioning of the nervous system.

  • Can pleasure be specifically removed through neurotransmitters?

    Yes, pleasure can be specifically removed through neurotransmitters. For example, drugs that target the dopamine system, such as certain antipsychotic medications, can reduce feelings of pleasure and reward. By altering the levels of neurotransmitters in the brain, it is possible to dampen or eliminate the experience of pleasure in certain situations. However, it is important to note that this can have negative consequences on overall mental health and well-being.

  • What happens if neurotransmitters are not removed?

    If neurotransmitters are not removed from the synaptic cleft, they can continue to stimulate the postsynaptic neuron, leading to prolonged signaling and potential overstimulation. This can disrupt the normal functioning of the nervous system and lead to issues such as anxiety, depression, or other neurological disorders. Additionally, the accumulation of neurotransmitters in the synaptic cleft can also interfere with the release of new neurotransmitters, further disrupting communication between neurons. Therefore, the timely removal of neurotransmitters is crucial for maintaining proper neuronal function.

  • What are the neurotransmitters in the brain?

    Neurotransmitters are chemical messengers that transmit signals between neurons in the brain. Some of the major neurotransmitters in the brain include serotonin, dopamine, norepinephrine, and gamma-aminobutyric acid (GABA). These neurotransmitters play important roles in regulating mood, emotions, cognition, and various physiological functions. Imbalances in these neurotransmitters have been linked to various mental health disorders such as depression, anxiety, and schizophrenia.

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    How productivity culture and technology became emblematic of the American economic system in pre- and postwar Germany. The concept of productivity originated in a statistical measure of output per worker or per work-hour, calculated by the US Bureau of Labor Statistics.A broader productivity culture emerged in 1920s America, as Henry Ford and others linked methods of mass production and consumption to high wages and low prices.These ideas were studied eagerly by a Germany in search of economic recovery after World War I, and, decades later, the Marshall Plan promoted productivity in its efforts to help post-World War II Europe rebuild.In Productivity Machines, Corinna Schlombs examines the transatlantic history of productivity technology and culture in the two decades before and after World War II.She argues for the interpretive flexibility of productivity: different groups viewed productivity differently at different times.Although it began as an objective measure, productivity came to be emblematic of the American economic system; post-World War II West Germany, however, adapted these ideas to its own political and economic values.Schlombs explains that West German unionists cast a doubtful eye on productivity's embrace of plant-level collective bargaining; unions fought for codetermination-the right to participate in corporate decisions.After describing German responses to US productivity, Schlombs offers an in-depth look at labor relations in one American company in Germany-that icon of corporate America, IBM.Finally, Schlombs considers the emergence of computer technology-seen by some as a new symbol of productivity but by others as the means to automate workers out of their jobs.

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  • Can one specifically remove pleasure through neurotransmitters?

    It is possible to influence pleasure through neurotransmitters by affecting the release, reuptake, or reception of certain neurotransmitters in the brain. For example, drugs such as opioids can increase feelings of pleasure by binding to opioid receptors and increasing the release of dopamine. Conversely, certain medications or conditions can decrease pleasure by reducing the activity of dopamine or other neurotransmitters. However, it is not possible to specifically and completely remove pleasure through neurotransmitters without also affecting other essential brain functions. The brain is a complex system, and pleasure is influenced by a combination of neurotransmitters and neural circuits.

  • Is the enzyme inhibited for the destruction of neurotransmitters?

    Yes, enzymes can be inhibited for the destruction of neurotransmitters. For example, the enzyme monoamine oxidase (MAO) is responsible for breaking down neurotransmitters such as serotonin, dopamine, and norepinephrine. Certain drugs, such as MAO inhibitors, can block the activity of MAO, leading to an increase in neurotransmitter levels in the brain. This can have therapeutic effects in conditions such as depression and anxiety.

  • Does it lead to a prolonged excitation when the neurotransmitters...

    Yes, prolonged excitation can occur when neurotransmitters are not properly reabsorbed or broken down. This can happen when there is a dysfunction in the reuptake process or when there is an excess of neurotransmitters in the synaptic cleft. Prolonged excitation can lead to overstimulation of the postsynaptic neuron, which can have negative effects on the nervous system and contribute to conditions such as anxiety, seizures, or neurodegenerative diseases. Therefore, proper regulation of neurotransmitter levels and reuptake processes is crucial for maintaining healthy nervous system function.

  • How does the release of neurotransmitters occur directly before death?

    As the body approaches death, the brain experiences a surge of electrical activity, leading to the release of neurotransmitters. This surge in activity is thought to be the brain's response to the lack of oxygen and other metabolic changes that occur as the body shuts down. The release of neurotransmitters, such as dopamine and glutamate, can contribute to the hallucinations and altered states of consciousness that some people report experiencing as they near death. This surge in neurotransmitter release may also play a role in the phenomenon of near-death experiences.

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